) Promote Firefox adoption Firefox FAQ FAQ var windowObjectReference = null // global variable function openFFPromotionPopup ( ) (. See rel="noreferrer" for more information. If this feature is set, the browser will omit the Referer header, as well as set noopener to true. When noopener is used, non-empty target names, other than _top, _self, and _parent, are treated like _blank in terms of deciding whether to open a new browsing context. If this feature is set, the new window will not have access to the originating window via Window.opener and returns null. Specifies the distance in pixels from the top side of the work area as defined by the user's operating system where the new window will be generated. Specifies the distance in pixels from the left side of the work area as defined by the user's operating system where the new window will be generated. Specifies the height of the content area, including scrollbars. Specifies the width of the content area, including scrollbars. Note: The true value was introduced in March 2022.įor better compatibility with older browsers, use one of the other values. If popup is not enabled, and there are no window features declared, the new browsing context will be a tab. The UI features included in the popup window will be automatically decided by the browser, generally including an address bar only. If this feature is enabled, it requests that a minimal popup window be used. The following options are supported: popup These features include options such as the window's default size and position, whether or not to open a minimal popup window, and so forth. This name can be used as the target attribute ofĪ string containing a comma-separated list of window features in the form name=value - or for boolean features, just name. The special target keywords, _self, _blank, _parent, and _top, can also be used. If the name doesn't identify an existing context, a new context is created and given the specified name. target OptionalĪ string, without whitespace, specifying the name of the browsing context the resource is being loaded into. If an empty string ( "") is specified or this parameter is omitted, a blank page is opened into the targeted browsing context. Deprecated vrdisplaypointerunrestrictedĪ string indicating the URL or path of the resource to be loaded.Non-Standard Deprecated requestFileSystem().Non-Standard convertPointFromPageToNode().Non-Standard convertPointFromNodeToPage().
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Old Boys’ rugby club and continue up past Radyr Bridge ~ the river should stillīe on your left. Path just after the barrier bear left on to the road. Wheel” bear left following the cycle path through the houses, at the end of the On under the railway bridge, follow the cycle path. Hailey Park, and go past the car park, go through the gates and carry straight Past the start/finish for parkrun, continue following the river path up through Parkrun), keeping the river on your left. Turn right along the river path, then turn left over the Millenniumīridge, straight off the bridge and towards the Nursery (opposite way to You will run down the cross path to Blackweir Bridge and then Just off the main spine road through Pontcanna Fields, just down from theĬhanging rooms. The course will be marked with small orange and yellow plastic marker flags, as TheĬourse is 2 laps on the right hand side of the park. Onto the Spine Road, follow the Spine Road towards the start/finish, turn leftĭown the small slope and run around the triangle, re-join the Spine Road by theĪllotments, turn right and run through the start/finish, then repeat the wholeĪnd start/finish at the Western Avenue end ~ opposite the rugby club. Right between the SWALEC stadium and the Sports Centre and then right again Run past the back of the SWALEC stadium turn Re-join the Spine Road by the allotments, turn right and run through the Start/finish, turn left down the small slope and run around the triangle, Then right again onto the Spine Road, follow the Spine Road towards the Gardens and turn left along the cross path to Blackweir Bridge and then There are no distance markers on the course. Road through Pontcanna Fields, just up from the riding school. You will take part in parkrun as normal, but when you finish please come and see me before you register your finishing position, that way we know where in the results we have to look to make it easier for us. You must register before Friday, August 5th to guarantee one.ġ/2 Marathon Trail Race (Participants must be 18 years or older)ġ0K Fun Run: 13 - 18 years (Participants must be 13 years or older)Ĭost includes aid station support, timing, after race food and refreshments, a free Avery Brewing Company beer (must be 21 years or older) and a participant medal.The first event is being incorporated into Cardiff parkrun ( ), please be there early for the briefing and to collect your number. We have kept our race registration fee the same as previous years, but due to price inflation, T-Shirts are now optional for the 5K and 1K events, and available for $10.00. Registrations will close Friday August 26th at 12:00pm MST. Register HERE for the Calarat Challenge Trail Running Festival. Please note, there is a cap of 300 total participants! If you would like to make a donation to Cal-wood Education Center, please go HERE.ĭon’t miss out on one of the few trail races in Boulder County. We will have food, beer, and music, so come on up and enjoy everything Cal-wood has to offer. You can then roll out of bed to the start line, and after the race, celebrate your accomplishment with your family, friends, and fellow participants at our after race party. We have lodging for the night before the race, as well as a great dinner prepared. Cal-Wood provides outdoor experiences, specifically outreaching to low-income and minority groups and race proceeds will allow Cal-wood to increase access to outdoor education experiences and life transforming opportunities for youth and low-income families. The Calarat Challenge Trail Running Festival is a promotion of health, fun and fitness to support the Cal-Wood Education Center, a 501 (c) 3 not-for-profit organization. It's run on a number of different trails throughout the beautiful private properties of Cal-Wood and Balarat Outdoor Education Center. This is a 1/2M, 10K, 5K and Kids 1K trail race that starts and finishes at the Cal-Wood Education Center. Join us Sunday, August 28th for the Calarat Challenge Trail Running Festival. Want to be a race volunteer? Then sign up HERE. Want to be an event sponsor? Options HERE. Calarat Challenge TRAIL RUNNING FESTIVAL sUnday, august 28 13–15 Overall the neuropathy associated with NEFL mutations is axonal and, to date, there is no convincing evidence that primary demyelination contributes to the pathogenesis of NEFL-related CMT. In CMT, heterozygous mutations in NEFL cause autosomal dominant CMT1 or CMT2, 12 whereas biallelic mutations cause an early onset and severe axonal neuropathy with associated slow conduction velocities. 1 9 Furthermore, single-nucleotide polymorphisms and deletions in the KSP repeat motifs of the NEFH tail domain have specifically been associated with an increased risk of ALS. There is evidence that accumulation of NFs either as stand-alone aggregates or as part of neurofibrillary tangles or Lewy bodies plays a role in neurodegenerative conditions of the CNS such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and Parkinson’s disease and of the PNS such as Charcot-Marie-Tooth disease (CMT), and it is not a surprise that they are explored as potential biomarkers for these diseases. 3 6 7 Various pieces of evidence illustrate the important roles the NEFH carboxyl terminus plays at different stages in neuronal development and especially in axonal radial expansion and maintenance. The tail domains of NEFM and NEFH contain multiple repeat motifs of lysine-serine-proline amino acids (KSP repeats) which act as phosphorylation sites with important roles in interfilament cross-bridging and axonal calibre expansion and stabilisation. This suggests a selective role of NEFH in the formation of interfilament cross-bridges, a function which is most prevalent in mature axons. 1 3 Immunofluorescence thin-section studies from healthy mammalian neurons show NEFH subunits primarily located at interfilament cross-bridges and being sparse or absent from neuronal cell bodies. The architectural assembly of NFs relies, among others, on two important factors: first, the line-up and appropriate association of conserved alpha-helical rod domains on opposing NF molecules, and second, the inherent property of NFs to form cross-bridges between them. All three NF triplet proteins share a common structure consisting of three components: a head domain (non-helical amino terminus), a central alpha-helical rod domain and a tail domain (non-helical carboxyl terminus). 1 3Įxperimental studies on NFs over the past four decades have provided us with a wealth of knowledge on their expression, structure, assembly, transport and function. 1 2 Peripherin and α-internexin are other NF components of the neuronal cytoskeleton in the peripheral nervous system (PNS) and central nervous system (CNS), respectively. They assemble as heteropolymers to become the major scaffolding component of the mature neuronal cytoskeleton in both peripheral and central neurons, and they primarily have a structural role in determining axonal calibre. 1 The majority of them are the NF triplet subunit proteins that are classified according to their gel electrophoresis-derived molecular weight into heavy (NEFH, 205 kDa), medium (NEFM, 160 kDa) and light (NEFL, 68 kDa) subunits. Neurofilaments (NFs) are intermediate filaments with an average diameter of 10 nm that are almost exclusively expressed in neurons. The lost carbon dioxide causes the body to become more alkaline. The increased respiratory rate begins within the first few hours of arriving at altitudes as low as 5,000 feet. Hydration is also key, we urinate out the bodies over production of alkaline that make us sick. Slow and steady wins the race when it comes to low oxygen environments. This means a safer and more enjoyable experience for you. With over 15 years of high altitude experience we have developed unique itineraries with additional acclimatization. Our experience had led us to having 3 nights in Namche Bazaar before, moving higher. We run usually have 250+ people trekking in the Everest region annually. Ian Taylor Trekking has helped over 3,600 people reach Everest Base Camp at 5,364/ 17,500 feet. Diamox is a diuretic so you do need to manage your hydration carefully. Taking Diamox before going on a trek to altitude is important, to make sure there are no major side effects. Importantly, your doctor can give you clear advice on traveling to a low oxygen environment. Your doctor will know your medical history best. It is always worth having a full health check up with your doctor. Remember, Diamox might not be recommended for you personally. 125mg in the morning and 125mg in the afternoon. School Tours School Expeditions with Ian Taylor TrekkingĪre there alternatives to taking Diamox at High Altitude? Our high altitude doctors and specialists recommend taking Diamox from the first day of your trip.Group Charity Trekking Adventures with Ian Taylor Trekking. Upgrade to JusTalk Plus: enjoy ads-free, special ringtones and themes. Upgrade to JusTalk Premium: enjoy all exclusive features including 10 free credits and a special price of Out Call, 720p HD quality video calls, ads-free, special ringtones, and themes. Save 40-90% of the voip or vowifi network traffic during realtime video calling with 720P HD quality. Enjoy safe and free calls.Ĭreate your own unique JusTalk ID and make your friends easy to search your account add new friends by shared name cards or QR codes. Moreover, all personal data is never shared with any third party. 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Make HD-quality voice or video calls with your friends and family for free over Wi-Fi or on-the-go (2.5G/3G/4G/5G)*, even if they're in another country.ĭoodle, record your call, play games, and share photos with your friends and family to liven up your conversation during calls. It's simple, reliable, secure, private, and fun, so you can enjoy face to face time with family and friends together, and never miss wonderful group or duo moments. JusTalk is a FREE high-quality video calling and messaging app for everyone. It's no surprise that there are a number of video games that have picked up on this style of play. The enjoyment comes from doing something that isn't learning or achieving anything. While that initial trend subsided, the interest and enjoyment of tactile objects to fiddle with are very much with us.įidget toys are like the yo-yo or Rubik's cube but without the focus on skill. These games all have in common, a complex control system that can be put to use in imaginative and creative ways to get the edge over your opponents.įidget spinners burst into the hands of children a number of years ago. Or it could be learning the complex move lists in a game like Street Fighter. Maybe it’s learning the perfect combination of angles and trajectories in Videoball. Or, perhaps, it’s using the limited running and jumping slightly better than other players to get a win in Fall Guys. This might be understanding how the propulsion of your car lets you take to the air and hit a perfect shot in Rocket League. Whether you rise through the league tables, or just improve compared to your family, the satisfaction or getting to grips with something so monumentally challenging is really satisfying. Rather than offering assistance, these games leave you to it. Rather than relying on the stats of your character or player, you have to execute the moves yourself with timing proficiency and instinct. Whereas many games simplify getting around, these games make the complexity and depth of their movement systems part of the joy of playing them. There are a small group of games that hone this challenge down to the mechanics of moving around the environment. It takes time to understand their systems, mechanics, objectives and worlds. When someone plays a game too much it’s easy to think they are taking an easy route to something entertaining, like junk food. Bomb Rush Cyberfunk will launch sometime in 2022 for PC and home consoles.Games offer us challenges on many levels. While we wait we can always look forward to Hideki Naganuma Twitter feed and just laugh/wonder what is going through his head today. Hopefully, we’ll find out more throughout the year on the release date and which platforms it will launch on. No further information was given for this, but it will more than likely be the current/last generation of systems. Another major change is that Bomb Rush Cyberfunk will also no longer be exclusive to the PC platform, as the studio also stated that the game will “come to consoles as well.” No official reason was given for this, but since there was never a concrete date/time frame to begin with it, technically, it doesn’t count as a delay. This appears to no longer be the case as the studio is now giving it a 2022 release instead. When the game was initially announced, it was expected to release sometime in 2021. Even the name Bomb Rush Cyberfunk sounds like something from the Sega Dreamcast era, and it’s sure to appeal to a lot of fans from that generation. The art style, gameplay, and overall presentation made us completely reminisce about Jet Set Radio, which is exactly what Team Reptile wanted. We’re also given an amazing sample of music from Hideki Naganuma, which was more than enough for us to dance to. The new trailer, which is only 33 seconds, gives us a small taste of the awesome foot-grinding that you’ll do with your character, with boosted jet-packs to boot. You’ll want to check forums, email them to measure their response time, try online chat if they have such services, check if they have an easy to follow guide on their website and FAQs section. When you encounter a problem, you want to pick up the phone and get some help from them as fast as possible rather than figuring it out yourself, without knowing what to do. A service provider that has poor customer service will be of no help in case you mess up. Therefore, customer service is key when searching for the best online backup service. Since computers do crash from time to time, you want to be prepared for anything. This is the last thing a photographer wants to deal with. When a computer crashes, it causes panic and frustration. This is a good amount of storage but will run out in a few years or a year for those that take a lot of pictures. A photo session will have an average of 100 to 200 photos. With one terabyte of storage, 100000 to 200000 photos can be stored. Just a quick math to justify it, an average high definition photo is about 5 to 10 MB in size. As a photographer, he/she will need more data storage space and even 1 TB may not be enough. The best are those that provide unlimited storage at no extra cost. If an online backup service offers less than 1 TB of storage, then eliminate it from a possible backup solution. The question is how much storage is enough? The minimum should be 1 TB. It is obvious that online backup services cannot lack space. The storage space is one the factors that is of high priority that needs to be considered. Those that directly eliminate photographers have been left out such as the elimination of online services tailored for personal use. Some will not be considered because this article focuses on photographers specifically. The following actions helped select the best backup solution. Their focus was on complete backup of a computer. They reviewed some popular storage services such as Dropbox to some names that are not known. To get a well-rounded perspective, they consulted IT security experts and personally tested the finalists by analyzing their security, customer support services, and usability. The team tested 36 different online backup services, comparing and contrasting the storage capacity, transfer speed and overall user experience. If you want to learn more about creating a backup workflow that works for your business, the ebook Backup or Die – How to Keep Your Photos Safe is a good resource from Photography Concentrate. has done the research for you to find the best online backup service to choose. A photographer is always taking photos of high resolution, and some photos may be as big as 20MB. Some of the people that find it hard to choose an online backup solution are photographers. Applying the “Backup Rule of Three” will help make the right solution. Old ways of backups are good but they cannot be compared to an online backup. Also, in case you lose the local storage drive or it is stolen, you can restore them to your new location from the online backup. One advantage is that it is easy to access the data at any time and from any location. There are many benefits for photographers to have an online data backup service. The best backup solution is one that is easy to use, has an automatic backup, and is safe. Those who have lost data will be looking for a solution and cloud is one of them. Most people will realize the importance of data backup when it is too late, and they have lost data. With no backup, the risk of losing the data is high, especially if the laptop or storage device gets destroyed or stolen (a photographer’s worst nightmare). Getting a cloud backup solution that suits your need is not as easy as it sounds. This information led the team at to believe that more people, especially photographers, need to be informed about the importance of backing up their files. Still, over 30% of people have never backed up their data, and only 10% safeguard their files weekly. And with 900 billion photos being uploaded every year, photographers need to make sure they are keeping their files safe. Opinions expressed are based on the Author’s own experience.Īccording to statistics, 140,000 hard drives crash in the United States every week. As an Amazon Associate I earn from qualifying purchases. **This post contains affiliate links and I will be compensated if you make a purchase after clicking through my links. Your work is brilliant!! Very creative and lovely enjoying it immensely Comment by DELAFLORīonita cancion Ren Comment by The Rolling Egg Rolls Very nice voice !!! ( something like "London Grammar" ) Comment by doccrax the subtle, understated percussion allows the vocals the room they deserve Comment by Gina Woodīeautiful emotive Your voice shines!! Comment by Pascal Basso Loving this.gorgeous music and vocals Comment by □ *thommo*Īnother Ren gem □ full of those wonderful emotive and atmospheric vocals. Love minimal atmosphere□□□□□ Comment by gigi Really good voise Comment by Yankel Muromachi Lovely performance Ren! Comment by Mr Teapot Lovely song and really love your harmonies - great work! Comment by Emilio GS I really like the minimal arrangement choices in here, it gives all the space to the amazing lead vocals and the back vocal harmonies, maybe a cappella version of this song will sound as good as this version is, because the vocals are so very well done. Mesmerising, held my attention thought out enjoyed…. Good work ! Comment by Vjekoslav BoricĪ brilliant and fairytale spectrum of sounds. The intervals used by the adding voice are effective and sound good. sorry, got lost with the txt a bit :) Comment by Gaz Roach unsafety, maybe anxiousness? but still, there is this will to keep going. your wonderful voice and the guitar?floating reverbed? stuff adds some wide open space. this little simple drum pattern creates this soft and sublte beat, like a slow walk. There is some fragility in this one here. So well made song and produced!! 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